Enhanced Anti-Skin Aging Effects of Fermented Black Ginseng (Panax ginseng C.A. Meyer) by Aspergillus niger KHNT-1

Functional foods to prevent aging, particularly skin have grown in popularity as society ages and science uncovers the pathological mechanisms of aging. In this study, we used processed ginseng, one famous functional foods, along with fermentation utilizing novel Aspergillus niger strain KHNT-1 enhance its value efficacy. We successfully produced fermented black ginseng (FBG) investigated anti-skin aging properties, such anti-melanogenic, anti-wrinkle, antioxidant activities. The results showed that FBG at 100 μg/mL inhibited tyrosinase melanin production IBMX-stimulated B16F10 cells. significantly reduced tyrosinase, TYRP-1, MITF mRNA expression. Moreover, stimulated anti-wrinkle effects UVB-irradiated human dermal fibroblast cells by inhibiting elastase activity, decreasing MMP-1 MMP-9 while increasing COL-1 Furthermore, activity reducing ROS levels H2O2-induced HaCat All tests had better activities than (BG) white (WG). Interestingly, lower toxicity B16F10, HDF, compared BG. Thus, study discovers underlying mechanism a material anti-skin-aging properties.